Prolonged delirium during hospitalization is associated with worse long-term and short-term outcomes in patients with acute heart failure.
Int J Cardiol
; 399: 131776, 2024 Mar 15.
Article
in En
| MEDLINE
| ID: mdl-38216062
ABSTRACT
BACKGROUND:
The association between prolonged delirium during hospitalization and long-term prognosis in patients with acute heart failure (AHF) admitted to the cardiac intensive care unit (CICU) has not been fully elucidated.METHODS:
We conducted a prospective registry study of patients with AHF admitted to the CICU at 2 hospitals from 2013 to 2021. We divided study patients into 3 groups according to the presence or absence of delirium and prolonged delirium as follows no delirium, resolved delirium, or prolonged delirium. Main outcomes were in-hospital mortality and 3-year mortality after discharge.RESULTS:
A total of 1555 patients with AHF (median age, 80 years) were included in the analysis. Of these, 406 patients (26.1%) developed delirium. We divided patients with delirium into 2 groups the resolved delirium group (n = 201) or the prolonged delirium group (n = 205). Multivariate Cox proportional hazards models for long-term prognosis demonstrated that the prolonged delirium group had a higher incidence of all-cause death (hazard ratio [HR], 1.52; 95% CI, 1.08 to 2.14) and non-cardiovascular death (HR, 1.84; 95% CI, 1.21 to 2.78) than the resolved delirium group. Regarding in-hospital outcomes, multivariate logistic regression modeling showed that prolonged delirium is associated with all-cause death (odds ratio [OR], 9.55; 95% confidential interval [CI], 2.99 to 30.53) and cardiovascular death (OR, 13.02; 95% CI, 2.86 to 59.27) compared with resolved delirium.CONCLUSIONS:
Prolonged delirium is associated with worse long-term and short-term outcomes than resolved delirium in patients with AHF.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Delirium
/
Heart Failure
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged80
/
Humans
Language:
En
Journal:
Int J Cardiol
/
Int. j. cardiol
/
International journal of cardiology
Year:
2024
Document type:
Article
Country of publication: