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Diagnostic accuracy of research criteria for prodromal frontotemporal dementia.
Benussi, Alberto; Premi, Enrico; Grassi, Mario; Alberici, Antonella; Cantoni, Valentina; Gazzina, Stefano; Archetti, Silvana; Gasparotti, Roberto; Fumagalli, Giorgio G; Bouzigues, Arabella; Russell, Lucy L; Samra, Kiran; Cash, David M; Bocchetta, Martina; Todd, Emily G; Convery, Rhian S; Swift, Imogen; Sogorb-Esteve, Aitana; Heller, Carolin; van Swieten, John C; Jiskoot, Lize C; Seelaar, Harro; Sanchez-Valle, Raquel; Moreno, Fermin; Laforce, Robert Jr; Graff, Caroline; Synofzik, Matthis; Galimberti, Daniela; Rowe, James B; Masellis, Mario; Tartaglia, Maria Carmela; Finger, Elizabeth; Vandenberghe, Rik; Mendonça, Alexandre; Tiraboschi, Pietro; Butler, Chris R; Santana, Isabel; Gerhard, Alexander; Le Ber, Isabelle; Pasquier, Florence; Ducharme, Simon; Levin, Johannes; Sorbi, Sandro; Otto, Markus; Padovani, Alessandro; Rohrer, Jonathan D; Borroni, Barbara.
Affiliation
  • Benussi A; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P.le Spedali Civili 1, 25123, Brescia, Italy.
  • Premi E; Neurology Unit, Department of Neurological and Vision Sciences, ASST Spedali Civili di Brescia, 25123, Brescia, Italy.
  • Grassi M; Vascular Neurology Unit, Department of Neurological and Vision Sciences, ASST Spedali Civili di Brescia, 25123, Brescia, Italy.
  • Alberici A; Department of Brain and Behavioral Science, Medical and Genomic Statistics Unit, University of Pavia, 27100, Pavia, Italy.
  • Cantoni V; Neurology Unit, Department of Neurological and Vision Sciences, ASST Spedali Civili di Brescia, 25123, Brescia, Italy.
  • Gazzina S; Department of Molecular and Translational Medicine, University of Brescia, 25123, Brescia, Italy.
  • Archetti S; Department of Neurological and Vision Sciences, Neurophysiology Unit, ASST Spedali Civili di Brescia, 25123, Brescia, Italy.
  • Gasparotti R; Biotechnology Laboratory, Department of Diagnostics, ASST Spedali Civili di Brescia, 25123, Brescia, Italy.
  • Fumagalli GG; Department of Medical and Surgical Specialties, Neuroradiology Unit, University of Brescia, 25123, Brescia, Italy.
  • Bouzigues A; Center for Mind/Brain Sciences-CIMeC, University of Trento, 38068, Rovereto, Italy.
  • Russell LL; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
  • Samra K; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
  • Cash DM; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
  • Bocchetta M; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
  • Todd EG; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
  • Convery RS; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
  • Swift I; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
  • Sogorb-Esteve A; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
  • Heller C; UK Dementia Research Institute at UCL, London, WC1E 6BT, UK.
  • van Swieten JC; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
  • Jiskoot LC; UK Dementia Research Institute at UCL, London, WC1E 6BT, UK.
  • Seelaar H; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
  • Sanchez-Valle R; UK Dementia Research Institute at UCL, London, WC1E 6BT, UK.
  • Moreno F; Department of Neurology, Erasmus Medical Centre, Rotterdam, 3015 GD, The Netherlands.
  • Laforce RJ; Department of Neurology, Erasmus Medical Centre, Rotterdam, 3015 GD, The Netherlands.
  • Graff C; Department of Neurology, Erasmus Medical Centre, Rotterdam, 3015 GD, The Netherlands.
  • Synofzik M; Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clinic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, 08036, Barcelona, Spain.
  • Galimberti D; Cognitive Disorders Unit, Department of Neurology, Donostia University Hospital, 20014, San Sebastian, Gipuzkoa, Spain.
  • Rowe JB; Neuroscience Area, Biodonostia Health Research Institute, 20014, San Sebastian, Gipuzkoa, Spain.
  • Masellis M; Clinique Interdisciplinaire de Mémoire, Département des Sciences Neurologiques, CHU de Québec, and Facultéde Médecine, Université Laval, Quebec City, Québec, G1V 0A6, Canada.
  • Tartaglia MC; Center for Alzheimer Research, Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Bioclinicum, Karolinska Institutet, 141 52, Solna, Sweden.
  • Finger E; Unit for Hereditary Dementias, Theme Aging, Karolinska University Hospital, 141 52, Solna, Sweden.
  • Vandenberghe R; Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tubingen, 72076, Tubingen, Germany.
  • Mendonça A; Center for Neurodegenerative Diseases (DZNE), 72076, Tübingen, Germany.
  • Tiraboschi P; Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 20122, Milan, Italy.
  • Butler CR; Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122, Milan, Italy.
  • Santana I; Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust and Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, CB2 7EF, UK.
  • Gerhard A; Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, ON, M4N 3M5, Canada.
  • Le Ber I; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, M5S, Canada.
  • Pasquier F; Department of Clinical Neurological Sciences, University of Western Ontario, London, ON, N6A 3K7, Canada.
  • Ducharme S; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, 3001, Leuven, Belgium.
  • Levin J; Neurology Service, University Hospitals Leuven, 3000, Leuven, Belgium.
  • Sorbi S; Leuven Brain Institute, KU Leuven, 3001, Leuven, Belgium.
  • Otto M; Faculty of Medicine, University of Lisbon, 1649-028, Lisbon, Portugal.
  • Padovani A; Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133, Milan, Italy.
  • Rohrer JD; Nuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford, Oxford, OX3 9DU, UK.
  • Borroni B; Department of Brain Sciences, Imperial College London, London, SW7 2BX, UK.
Alzheimers Res Ther ; 16(1): 10, 2024 01 12.
Article in En | MEDLINE | ID: mdl-38216961
ABSTRACT

BACKGROUND:

The Genetic Frontotemporal Initiative Staging Group has proposed clinical criteria for the diagnosis of prodromal frontotemporal dementia (FTD), termed mild cognitive and/or behavioral and/or motor impairment (MCBMI). The objective of the study was to validate the proposed research criteria for MCBMI-FTD in a cohort of genetically confirmed FTD cases against healthy controls.

METHODS:

A total of 398 participants were enrolled, 117 of whom were carriers of an FTD pathogenic variant with mild clinical symptoms, while 281 were non-carrier family members (healthy controls (HC)). A subgroup of patients underwent blood neurofilament light (NfL) levels and anterior cingulate atrophy assessment.

RESULTS:

The core clinical criteria correctly classified MCBMI vs HC with an AUC of 0.79 (p < 0.001), while the addition of either blood NfL or anterior cingulate atrophy significantly increased the AUC to 0.84 and 0.82, respectively (p < 0.001). The addition of both markers further increased the AUC to 0.90 (p < 0.001).

CONCLUSIONS:

The proposed MCBMI criteria showed very good classification accuracy for identifying the prodromal stage of FTD.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Frontotemporal Dementia Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Alzheimers Res Ther Year: 2024 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Frontotemporal Dementia Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Alzheimers Res Ther Year: 2024 Document type: Article Affiliation country: Country of publication: