Management of liver and gastrointestinal toxicity induced by immune checkpoint inhibitors: Position statement of the AEEH-AEG-SEPD-SEOM-GETECCU.
Rev Esp Enferm Dig
; 116(2): 83-113, 2024 Feb.
Article
in En
| MEDLINE
| ID: mdl-38226597
ABSTRACT
The development of the immune checkpoint inhibitors (ICI) is one of the most remarkable achievements in cancer therapy in recent years. However, their exponential use has led to an increase in immune-related adverse events (irAEs). Gastrointestinal and liver events encompass hepatitis, colitis and upper digestive tract symptoms accounting for the most common irAEs, with incidence rates varying from 2 % to 40 %, the latter in patients undergoing combined ICIs therapy. Based on the current scientific evidence derived from both randomized clinical trials and real-world studies, this statement document provides recommendations on the diagnosis, treatment and prognosis of the gastrointestinal and hepatic ICI-induced adverse events.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Colitis
/
Gastrointestinal Diseases
Type of study:
Clinical_trials
/
Guideline
Limits:
Humans
Language:
En
Journal:
Rev Esp Enferm Dig
Journal subject:
GASTROENTEROLOGIA
Year:
2024
Document type:
Article
Country of publication: