Vitamin D deficiency in patients with cystic fibrosis: a systematic review and meta-analysis.
J Health Popul Nutr
; 43(1): 11, 2024 Jan 17.
Article
in En
| MEDLINE
| ID: mdl-38233891
ABSTRACT
AIM:
Vitamin D is a prominent modulator of immunity and respiratory function. It plays a vital role in respiratory diseases such as cystic fibrosis (CF). S. However, there is a dearth of information on patients with CF. The purpose of the meta-analysis is to highlight the importance of following the existing guidelines regarding maintenance of Vitamin D serum levels in patients with CF.METHODS:
The systematic search was conducted without utilizing any time or language limitations in original database from the beginning until March 2022. The meta-analysis was performed using a random-effects model. Heterogeneity was determined by I2 statistics and Cochrane Q test.RESULTS:
Pooled analysis using the random-effects model of the 8 case-control studies with 13 effect sizes revealed that the serum 25-OH-vitamin D in participants with cystic fibrosis was significantly lower than controls in pediatrics and adolescences (WMD - 3.41 ng/ml, 95% CI - 5.02, - 1.80, p = < 0.001) and adults (WMD - 2.60 ng/ml, 95% CI - 4.32, - 0.89, p = 0.003). Based on data from 12 studies (21 effect sizes) with a total of 1622 participants, the prevalence of vitamin D levels of 20-30 ng/ml in CF patients was 36% among pediatrics/adolescents and 63% among adults. In addition, 27% of pediatric/adolescent CF patients and 35% of adult CF patients had vitamin D levels of below 20 ng/ml.CONCLUSIONS:
As a result, according to the existing guidelines, our results proved the need to pay attention to the level of vitamin D in these patients.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vitamin D Deficiency
/
Cystic Fibrosis
Type of study:
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
Limits:
Adolescent
/
Adult
/
Child
/
Humans
Language:
En
Journal:
J Health Popul Nutr
/
J. health popul. nutr
/
Journal of health, population, and nutrition
Journal subject:
CIENCIAS DA NUTRICAO
/
GASTROENTEROLOGIA
/
SAUDE PUBLICA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: