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Circulation, viral diversity and genomic rearrangement in mpox virus in the Netherlands during the 2022 outbreak and beyond.
Schuele, Leonard; Boter, Marjan; Nieuwenhuijse, David F; Götz, Hannelore; Fanoy, Ewout; de Vries, Henry; Vieyra, Bruno; Bavalia, Roisin; Hoornenborg, Elske; Molenkamp, Richard; Jonges, Marcel; van den Ouden, Anton; Simões, Margarida; van den Lubben, Mariken; Koopmans, Marion; Welkers, Matthijs R A; Oude Munnink, Bas B.
Affiliation
  • Schuele L; Department of Viroscience, Erasmus MC University Medical Center, Rotterdam, Netherlands.
  • Boter M; Department of Viroscience, Erasmus MC University Medical Center, Rotterdam, Netherlands.
  • Nieuwenhuijse DF; Department of Viroscience, Erasmus MC University Medical Center, Rotterdam, Netherlands.
  • Götz H; Department of Viroscience, Erasmus MC University Medical Center, Rotterdam, Netherlands.
  • Fanoy E; Department of Public Health, (Infectious Disease Control and Center Sexual Health) Public Health Service Rotterdam-Rijnmond, Rotterdam, Netherlands.
  • de Vries H; Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, Netherlands.
  • Vieyra B; Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, Netherlands.
  • Bavalia R; Department of Dermatology, Amsterdam UMC, Location University of Amsterdam, Amsterdam, Netherlands.
  • Hoornenborg E; Amsterdam Institute for Infection and Immunology, Infectious Diseases, Amsterdam, Netherlands.
  • Molenkamp R; Department of Public Health, (Infectious Disease Control and Center Sexual Health) Public Health Service Rotterdam-Rijnmond, Rotterdam, Netherlands.
  • Jonges M; Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, Netherlands.
  • van den Ouden A; Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, Netherlands.
  • Simões M; Amsterdam Institute for Infection and Immunology, Infectious Diseases, Amsterdam, Netherlands.
  • van den Lubben M; Department of Viroscience, Erasmus MC University Medical Center, Rotterdam, Netherlands.
  • Koopmans M; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, Netherlands.
  • Welkers MRA; Molecular Biology Systems BV, Goes, Netherlands.
  • Oude Munnink BB; Centre for Infectious Disease Control (CIb), National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
J Med Virol ; 96(1): e29397, 2024 01.
Article in En | MEDLINE | ID: mdl-38235923
ABSTRACT
Mpox is an emerging zoonotic disease which has now spread to over 113 countries as of August 2023, with over 89,500 confirmed human cases. The Netherlands had one of the highest incidence rates in Europe during the peak of the outbreak. In this study, we generated 158 near-complete mpox virus (MPXV) genomes (12.4% of nationwide cases) that were collected throughout the Netherlands from the start of the outbreak in May 2022 to August 2023 to track viral evolution and investigate outbreak dynamics. We detected 14 different viral lineages, suggesting multiple introductions followed by rapid initial spread within the country. The estimated evolutionary rate was relatively high compared to previously described in orthopoxvirus literature, with an estimated 11.58 mutations per year. Genomic rearrangement events occurred at a rate of 0.63% and featured a large deletion event. In addition, based on phylogenetics, we identified multiple potential transmission clusters which could be supported by direct source- and contact tracing data. This led to the identification of at least two main transmission locations at the beginning of the outbreak. We conclude that whole genome sequencing of MPXV is essential to enhance our understanding of outbreak dynamics and evolution of a relatively understudied and emerging zoonotic pathogen.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monkeypox virus / Genomics Limits: Humans Country/Region as subject: Europa Language: En Journal: J Med Virol Year: 2024 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monkeypox virus / Genomics Limits: Humans Country/Region as subject: Europa Language: En Journal: J Med Virol Year: 2024 Document type: Article Affiliation country: Country of publication: