Protocol for iron-catalyzed cross-electrophile coupling of aryl chlorides with unactivated alkyl chlorides.
STAR Protoc
; 5(1): 102846, 2024 Mar 15.
Article
in En
| MEDLINE
| ID: mdl-38265939
ABSTRACT
Organochlorides are a crucial class of electrophiles in organic synthesis. Here, we present a protocol for the cross-electrophile coupling of aryl chlorides with unactivated alkyl chlorides, facilitated by an iron/B2pin2 catalytic system. We describe steps for the coupling of aryl chlorides with alkyl chlorides, followed by purification of products. This protocol can produce alkylated products with up to 81% yield. For complete details on the use and execution of this protocol, please refer to Zhang et al.1.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chlorides
/
Iron
Language:
En
Journal:
STAR Protoc
Year:
2024
Document type:
Article