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Optimizing sexual reproductive health of men and women with cystic fibrosis: A systematic review.
Iyer, Anand G; Yu, Benjamin; Reddy, Amit; Khera, Mohit.
Affiliation
  • Iyer AG; School of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA. Electronic address: iyera@livemail.uthscsa.edu.
  • Yu B; Department of Urology, Baylor College of Medicine, 2457 S Braeswood Blvd, Houston, TX 77030, USA.
  • Reddy A; Department of Urology, Baylor College of Medicine, 2457 S Braeswood Blvd, Houston, TX 77030, USA.
  • Khera M; Department of Urology, Baylor College of Medicine, 2457 S Braeswood Blvd, Houston, TX 77030, USA.
J Cyst Fibros ; 2024 Feb 03.
Article in En | MEDLINE | ID: mdl-38311513
ABSTRACT
This systematic review summarizes the impact of cystic fibrosis (CF) on sexual and reproductive health (SRH) in males and females, covering pubertal development, hormonal function, family planning, and fertility. Included articles featured historical CF diagnostic criteria, preclinical or clinical data (retrospective cohorts or open label trials), while excluded articles lacked full text availability, explicit methodology, or comparisons between CF and non-CF patients. Genotype differences in CFTR mutations influenced symptom severity. Males with CF experienced delayed puberty, hypogonadism, infertility from obstructive azoospermia, and semen parameter issues. Female CF patients showed decreased fertility, possibly linked to disrupted ionic balance and ovarian cystic disease. Assistive reproductive technologies addressed fertility issues, but success varied based on disease severity and genotype. CFTR modulators aided pulmonary function and sexual health but require further assessment for fertility benefits.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Systematic_reviews Language: En Journal: J Cyst Fibros Year: 2024 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Systematic_reviews Language: En Journal: J Cyst Fibros Year: 2024 Document type: Article