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Oncogenic GNAS Uses PKA-Dependent and Independent Mechanisms to Induce Cell Proliferation in Human Pancreatic Ductal and Acinar Organoids.
Desai, Ridhdhi; Huang, Ling; Gonzalez, Raul S; Muthuswamy, Senthil K.
Affiliation
  • Desai R; Department of Medicine, Beth Israel Deaconess Medical Center, Cancer Research Institute, Harvard Medical School, Boston, Massachusetts.
  • Huang L; Department of Medicine, Beth Israel Deaconess Medical Center, Cancer Research Institute, Harvard Medical School, Boston, Massachusetts.
  • Gonzalez RS; Department of Medicine, Beth Israel Deaconess Medical Center, Cancer Research Institute, Harvard Medical School, Boston, Massachusetts.
  • Muthuswamy SK; Laboratory of Cancer Biology and Genetics, NCI, NIH, Bethesda, Maryland.
Mol Cancer Res ; 22(5): 440-451, 2024 05 02.
Article in En | MEDLINE | ID: mdl-38319286
ABSTRACT
IMPLICATIONS The study identifies an opportunity to discover a PKA-independent pathway downstream of oncogene GNAS for managing IPMN lesions and their progression to PDAC.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Organoids / Chromogranins / Cyclic AMP-Dependent Protein Kinases / GTP-Binding Protein alpha Subunits, Gs / Cell Proliferation Limits: Humans Language: En Journal: Mol Cancer Res Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2024 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Organoids / Chromogranins / Cyclic AMP-Dependent Protein Kinases / GTP-Binding Protein alpha Subunits, Gs / Cell Proliferation Limits: Humans Language: En Journal: Mol Cancer Res Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2024 Document type: Article Country of publication: