Synthesis of novel benzylamine antimycotics and evaluation of their antimycotic potency.
Arch Pharm (Weinheim)
; 357(5): e2300381, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38345272
ABSTRACT
A series of 23 novel benzylamines was synthesized by reductive amination from halogen-substituted 3- and 4-benzyloxybenzaldehyde derivatives and 6-methylhept-2-yl amine or n-octylamine. The antimycotic activity of the resulting amines was evaluated in a microdilution assay against the apathogenic yeast Yarrowia lipolytica as test microorganism. Promising compounds were also tested against human pathogenic Candida species. The influence of halogen substituents at the benzyl ether side chain was studied in this screening, as well as the influence of the branched side chain of (±)-6-methylhept-2-yl amine in comparison with the n-octyl side chain.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Benzylamines
/
Microbial Sensitivity Tests
/
Antifungal Agents
Limits:
Humans
Language:
En
Journal:
Arch Pharm (Weinheim)
Year:
2024
Document type:
Article
Affiliation country: