AMPK Alchemy: Therapeutic Potentials in Allergy, Aging, and Cancer.
Biomol Ther (Seoul)
; 32(2): 171-182, 2024 Mar 01.
Article
in En
| MEDLINE
| ID: mdl-38346909
ABSTRACT
All cells are equipped with intricate signaling networks to meet the energy demands and respond to the nutrient availability in the body. AMP-activated protein kinase (AMPK) is among the most potent regulators of cellular energy balance. Under ATP -deprived conditions, AMPK phosphorylates substrates and affects various biological processes, such as lipid/glucose metabolism and protein synthesis. These actions further affect the cell growth, death, and functions, altering the cellular outcomes in energy-restricted environments. AMPK plays vital roles in maintaining good health. AMPK dysfunction is observed in various chronic diseases, making it a promising target for preventing and alleviating such diseases. Herein, we highlight the different AMPK functions, especially in allergy, aging, and cancer, to facilitate the development of new therapeutic approaches in the future.
Full text:
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Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Biomol Ther (Seoul)
Year:
2024
Document type:
Article