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Door-to-diuretic time and mortality in patients with acute heart failure: A systematic review and meta-analysis.
Sampaio Rodrigues, Thalys; Garcia Quarto, Levindo Jose; Nogueira, Savio Carvalho; Theuerle, James D; Farouque, Omar; Burrell, Louise M; Koshy, Anoop N.
Affiliation
  • Sampaio Rodrigues T; Department of Cardiology, Austin Health, Melbourne, Victoria, Australia; Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia. Electronic address: thalys.sampaiorodrigues@unimelb.edu.au.
  • Garcia Quarto LJ; St Elizabeth Hospital, Boston, MA.
  • Nogueira SC; Beth Israel Deaconess Medical Center, Boston, MA.
  • Theuerle JD; Department of Cardiology, Austin Health, Melbourne, Victoria, Australia.
  • Farouque O; Department of Cardiology, Austin Health, Melbourne, Victoria, Australia; Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia.
  • Burrell LM; Department of Cardiology, Austin Health, Melbourne, Victoria, Australia; Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia.
  • Koshy AN; Department of Cardiology, Austin Health, Melbourne, Victoria, Australia; Icahn School of Medicine at Mount Sinai, New York, NY; Department of Cardiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Am Heart J ; 269: 205-209, 2024 Mar.
Article in En | MEDLINE | ID: mdl-38359992
ABSTRACT
Early decongestion therapy with intravenous diuretics may be associated with improved outcomes in acute heart failure (AHF), however data is conflicting. This meta-analysis sought to evaluate the impact of door-to-IV diuretic (D2D) time on mortality in patients with AHF. Pooled estimates from observational studies comprising 28,124 patients, early IV diuresis (reference time 30-105 minutes) was associated with a 23% reduction in 30-day mortality in AHF (OR 0.77; 95% CI 0.64-0.93), despite no significant in-hospital death reduction (OR 0.84; 95% CI 0.57-1.24).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diuretics / Heart Failure Type of study: Observational_studies / Systematic_reviews Limits: Humans Language: En Journal: Am Heart J Year: 2024 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diuretics / Heart Failure Type of study: Observational_studies / Systematic_reviews Limits: Humans Language: En Journal: Am Heart J Year: 2024 Document type: Article Country of publication: