Association between ACTN3 (R577X), ACE (I/D), BDKRB2 (-9/+9), and AGT (M268T) polymorphisms and performance phenotypes in Brazilian swimmers.
BMC Sports Sci Med Rehabil
; 16(1): 50, 2024 Feb 19.
Article
in En
| MEDLINE
| ID: mdl-38374123
ABSTRACT
BACKGROUND:
The influence of genetic polymorphisms on athletic performance has been widely explored. This study investigated the interactions between the polymorphisms ACTN3 (R577X), ACE (I/D), BDKRB2 (-9/+9), and AGT (M/T) and their association with endurance and strength phenotypes in Brazilian swimmers.METHODS:
123 athletes (aged 20-30 years) and 718 controls participated in the study. The athletes were divided into elite and sub-elite (N = 19 and 104, respectively) and strength and endurance experts (N = 98 and 25, respectively). Hardy-Weinberg equilibrium was observed in all groups.RESULTS:
Considering the ACE polymorphism, it was observed a higher frequency of the DD genotype than expected in the strength experts of the elite group, whereas the strength experts sub-elite athletes had a higher frequency of the ID genotype (χ2 = 8.17; p = 0.01). Subjects with XX genotypes of ACTN3 are more likely to belong to the athlete group when compared to the control group (OR = 1.79, p = 0.04). The DD homozygotes of the ACE are more likely to belong to the elite group with strength phenotypes than the group of sub-elite (OR = 7.96, p = 0.01) and elite strength experts compared to elite endurance (OR = 18.0, p = 0.03). However, no significant differences were observed in the allelic distribution of the polymorphisms evaluated when comparing Elite, sub-elite athletes and controls.CONCLUSION:
ACE and ACTN3 allele frequencies should be considered with regard to performance influencing factors in Brazilian swimmers.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
BMC Sports Sci Med Rehabil
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: