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3D bioprinting cowpea mosaic virus as an immunotherapy depot for ovarian cancer prevention in a preclinical mouse model.
Zhao, Zhongchao; Xiang, Yi; Koellhoffer, Edward C; Shukla, Sourabh; Fiering, Steven; Chen, Shaochen; Steinmetz, Nicole F.
Affiliation
  • Zhao Z; Department of NanoEngineering, University of California San Diego, 9500 Gilman Dr. La Jolla CA, 92093 USA chen168@ucsd.edu nsteinmetz@ucsd.edu.
  • Xiang Y; Center for Nano-ImmunoEngineering, University of California San Diego, 9500 Gilman Dr. La Jolla CA 92093 USA.
  • Koellhoffer EC; Moores Cancer Center, University of California San Diego, 9500 Gilman Dr. La Jolla CA 92093 USA.
  • Shukla S; Department of NanoEngineering, University of California San Diego, 9500 Gilman Dr. La Jolla CA, 92093 USA chen168@ucsd.edu nsteinmetz@ucsd.edu.
  • Fiering S; Department of Radiology, University of California San Diego, 9500 Gilman Dr. La Jolla CA 92093 USA.
  • Chen S; Department of NanoEngineering, University of California San Diego, 9500 Gilman Dr. La Jolla CA, 92093 USA chen168@ucsd.edu nsteinmetz@ucsd.edu.
  • Steinmetz NF; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth Lebanon NH 03756 USA.
Mater Adv ; 5(4): 1480-1486, 2024 Feb 19.
Article in En | MEDLINE | ID: mdl-38380337
ABSTRACT
Implantable polymeric hydrogels loaded with immunostimulatory cowpea mosaic virus (CPMV) were fabricated using digital light processing (DLP) printing technology. The CPMV-laden hydrogels were surgically implanted into the peritoneal cavity to serve as depots for cancer slow-release immunotherapy. Sustained release of CPMV within the intraperitoneal space alleviates the need for repeated dosing and we demonstrated efficacy against ovarian cancer in a metastatic mouse model.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Mater Adv Year: 2024 Document type: Article
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Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Mater Adv Year: 2024 Document type: Article