Immunotherapy targeting tumor-associated antigen in a mouse model of head and neck cancer.
Head Neck
; 46(8): 2056-2067, 2024 08.
Article
in En
| MEDLINE
| ID: mdl-38390628
ABSTRACT
BACKGROUND:
The identification of epitope peptides from tumor-associated antigens (TAAs) is informative for developing tumor-specific immunotherapy. However, only a few epitopes have been detected in mouse TAAs of head and neck cancer (HNSCC).METHODS:
Novel mouse c-Met-derived T-cell epitopes were predicted by computer-based algorithms. Mouse HNSCC cell line-bearing mice were treated with a c-Met peptide vaccine. The effects of CD8 and/or CD4 T-cell depletion, and vaccine combination with immune checkpoint inhibitors (ICIs) were evaluated. Tumor re-inoculation was performed to assess T-cell memory.RESULTS:
We identified c-Met-derived short and long epitopes that elicited c-Met-reactive antitumor CD8 and/or CD4 T-cell responses. Vaccination using these peptides showed remarkable antitumor responses via T cells in which ICIs were not required. The c-Met peptide-vaccinated mice rejected the re-inoculated tumors.CONCLUSIONS:
We demonstrated that novel c-Met peptide vaccines can induce antitumor T-cell response, and could be a potent immunotherapy in a syngeneic mouse HNSCC model.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cancer Vaccines
/
Disease Models, Animal
/
Head and Neck Neoplasms
/
Immunotherapy
/
Antigens, Neoplasm
Limits:
Animals
Language:
En
Journal:
Head & neck
/
Head Neck
/
Head neck
Journal subject:
NEOPLASIAS
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: