Do PET-positive supradiaphragmatic lymph nodes predict overall survival or the success of primary surgery in patients with advanced ovarian cancer?
Eur J Obstet Gynecol Reprod Biol
; 296: 13-19, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38394714
ABSTRACT
OBJECTIVES:
Compared to conventional computed tomography (CT), fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) detects higher rates of lymph node and distant metastases in patients with ovarian cancer. However, FDG-PET/CT is not routinely performed during preoperative work-up. Therefore, we investigated the prognostic value of preoperative FDG-PET/CT in advanced epithelial ovarian cancer (EOC) and its predictive value for surgical resection in patients with no residual disease. The potential significance of PET-positive supradiaphragmatic lymph nodes (SDLNs) for these parameters was evaluated.METHODS:
All patients with FIGO IIA-IVB EOC diagnosed between March 2014 and January 2021 at our certified gynaecological cancer centre, who underwent FDG PET/CT before primary surgery were retrospectively included.RESULTS:
Fifty-three consecutive patients were included in the study. Eighteen (34 %) patients had PET-positive SDLNs. We could not demonstrate a significant correlation between PET-positive SDLNs and median overall survival (OS; SDLN-positive 58.76 months, SDLN-negative 60.76 months; p = 0.137) or intra- or perioperative outcomes.CONCLUSIONS:
FDG PET/CT has a higher detection rate for SDLNs in patients with ovarian cancer than CT has, as described in the literature. Moreover, PET-positive SDLNs failed to predict intraoperative outcomes or overall survival.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ovarian Neoplasms
/
Positron Emission Tomography Computed Tomography
Limits:
Female
/
Humans
Language:
En
Journal:
Eur J Obstet Gynecol Reprod Biol
/
Eur. j. obstet. gynecol. reprod. biol
/
European journal of obstetrics gynecology and reproductive biology
Year:
2024
Document type:
Article
Country of publication: