[Research advances on the role of microRNA engineered exosomes in diabetic wounds].
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi
; 40(2): 190-195, 2024 Feb 20.
Article
in Zh
| MEDLINE
| ID: mdl-38418181
ABSTRACT
Diabetic wounds are a common complication in patients with diabetes, which is difficult to treat. Current treatment methods for diabetic wounds include debridement, functional dressing coverage, negative pressure therapy, bone cement filling, and skin grafting, etc. MicroRNA (miRNA) engineered exosomes have shown promising potential in diabetic wound repair due to the ability to alleviate inflammation, stimulate angiogenesis, and promote collagen deposition and re-epithelialization. Related researches are being actively carred out. This paper reviews the pathophysiological characteristics of diabetic wounds, the characteristics of miRNA and exosomes, the engineering methods for exosomes loaded with miRNA, and the mechanism of miRNA engineered exosomes in promoting healing of diabetic wounds, aiming to provide a reference basis for the future clinical application of miRNA engineered exosomes in diabetic wounds.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
MicroRNAs
/
Diabetes Mellitus
/
Exosomes
Limits:
Humans
Language:
Zh
Journal:
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: