Clinical, pathologic, and molecular characterization of a non-metastatic multicentric cutaneous mast cell tumor in a cow.
Vet Clin Pathol
; 53(1): 131-135, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38418393
ABSTRACT
Cutaneous mast cell tumors are rarely reported in cattle. Although mutations in the c-KIT gene have been shown to play a central role in the oncogenesis of canine mast cell tumors, few data are available in cattle. This report describes the clinical, histologic, immunohistochemical, and genetic features of a multicentric cutaneous mast cell tumor in an adult cow. An 11-year-old Prim'Holstein cow was presented for a 5-month history of multiple skin nodules. Cytologic and histologic analyses of the nodules led to a diagnosis of mast cell tumors. Immunohistochemical analysis for KIT expression showed a moderate to strong signal in neoplastic mast cells with a cytoplasmic and membranous pattern. Sequencing of the c-KIT gene coding sequence revealed no mutation. Despite partial response after corticosteroid treatment, euthanasia was elected. No metastases to the lymph nodes, spleen, and liver were identified at post-mortem and histologic examinations.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Neoplasms
/
Cattle Diseases
/
Dog Diseases
/
Mastocytoma, Skin
Limits:
Animals
Language:
En
Journal:
Vet Clin Pathol
Journal subject:
MEDICINA VETERINARIA
/
PATOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: