Early Organ Metastasis in Granulomatous Mycosis Fungoides: A Systematic Review.
Dermatology
; 240(3): 468-473, 2024.
Article
in En
| MEDLINE
| ID: mdl-38422999
ABSTRACT
BACKGROUND:
Granulomatous mycosis fungoides (GMF) is a rare form of cutaneous T-cell lymphoma characterized by a granulomatous inflammatory infiltrate.OBJECTIVE:
The impact of granulomatous inflammation on the prognosis of the disease remains controversial as there have been both favorable and unfavorable outcomes documented.METHODS:
We performed a systematic review of 116 GMF cases previously described in the literature.RESULTS:
In contrast to the classic Alibert-Bazin type of mycosis fungoides (MF), cutaneous lesions in GMF tend to involve distal extremities (lower legs, feet, hands) early in the disease course. In the literature, 30% of GMF patients developed organ metastasis, most frequently to the lung. The median time to stage progression was 25 months.CONCLUSION:
GMF is an aggressive form of MF. Therefore, screening for distant metastases should be considered at presentation and repeated during follow-up.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Neoplasms
/
Mycosis Fungoides
Limits:
Humans
Language:
En
Journal:
Dermatology
Journal subject:
DERMATOLOGIA
Year:
2024
Document type:
Article