Nucleosides are overlooked fuels in central carbon metabolism.
Trends Endocrinol Metab
; 35(4): 290-299, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38423899
ABSTRACT
From our daily nutrition and synthesis within cells, nucleosides enter the bloodstream and circulate throughout the body and tissues. Nucleosides and nucleotides are classically viewed as precursors of nucleic acids, but recently they have emerged as a novel energy source for central carbon metabolism. Through catabolism by nucleoside phosphorylases, the ribose sugar group is released and can provide substrates for lower steps in glycolysis. In environments with limited glucose, such as at sites of infection or in the tumor microenvironment (TME), cells can use, and may even require, this alternative energy source. Here, we discuss the implications of these new findings in health and disease and speculate on the potential new roles of nucleosides and nucleic acids in energy metabolism.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Nucleic Acids
/
Nucleosides
Limits:
Humans
Language:
En
Journal:
Trends Endocrinol Metab
/
Trends endocrinol. metab
/
Trends in endocrinology and metabolism
Journal subject:
ENDOCRINOLOGIA
/
METABOLISMO
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: