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Macro-clusters: CD301b+ DCs prime Th2 responses.
Abberger, Hanna; Groom, Joanna R.
Affiliation
  • Abberger H; Walter and Eliza Hall Institute of Medical Research , Parkville, Australia.
  • Groom JR; Department of Medical Biology, University of Melbourne, Parkville, Australia.
J Exp Med ; 221(4)2024 Apr 01.
Article in En | MEDLINE | ID: mdl-38442269
ABSTRACT
In this issue of JEM, Lyons-Cohen et al. (https//doi.org/10.1084/jem.20231282) reveal that lymph node macro-clusters provide a spatial niche where CD301b+ cDC2s and CD4+ T cells interact. These integrin-mediated cellular hubs promote enhanced co-stimulation and cytokine signaling to drive Th2 differentiation.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / Integrins Language: En Journal: J Exp Med Year: 2024 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / Integrins Language: En Journal: J Exp Med Year: 2024 Document type: Article Affiliation country: Country of publication: