Short-term hyperoxia induced mitochondrial respiratory chain complexes dysfunction and oxidative stress in lung of rats.
Inhal Toxicol
; 36(3): 174-188, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38449063
ABSTRACT
BACKGROUND:
Oxygen therapy is an alternative for many patients with hypoxemia. However, this practice can be dangerous as oxygen is closely associated with the development of oxidative stress.METHODS:
Male Wistar rats were exposed to hyperoxia with a 40% fraction of inspired oxygen (FIO2) and hyperoxia (FIO2 = 60%) for 120 min. Blood and lung tissue samples were collected for gas, oxidative stress, and inflammatory analyses.RESULTS:
Hyperoxia (FIO2 = 60%) increased PaCO2 and PaO2, decreased blood pH and caused thrombocytopenia and lymphocytosis. In lung tissue, neutrophil infiltration, nitric oxide concentration, carbonyl protein formation and the activity of complexes I and II of the mitochondrial respiratory chain increased. FIO2 = 60% decreased SOD activity and caused several histologic changes.CONCLUSION:
In conclusion, we have experimentally demonstrated that short-term exposure to high FIO2 can cause oxidative stress in the lung.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hyperoxia
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Inhal Toxicol
Journal subject:
TOXICOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: