The exceptions that prove the rule-a historical view of bedaquiline susceptibility.
Genome Med
; 16(1): 39, 2024 03 13.
Article
in En
| MEDLINE
| ID: mdl-38481348
ABSTRACT
In the accompanying study, Nimmo and colleagues estimated the dates of emergence of mutations in mmpR5 (Rv0678), the most important resistance gene to the anti-tuberculosis drug bedaquiline, in over 3500 geographically diverse Mycobacterium tuberculosis genomes. This provided important insights to improve the design and analysis of clinical trials, as well as the World Health Organization catalogue of resistance mutations, the global reference for interpreting genotypic antimicrobial susceptibility testing results.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Diarylquinolines
/
Mycobacterium tuberculosis
Limits:
Humans
Language:
En
Journal:
Genome Med
Year:
2024
Document type:
Article
Affiliation country: