Multimodality Imaging Features of Immunoglobulin G4-related Vessel Involvement.
Radiol Cardiothorac Imaging
; 6(2): e230105, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38483247
ABSTRACT
Immunoglobulin 4 (IgG4)-related disease is a chronic immune-mediated fibroinflammatory disorder. Involvement of the vascular system, including large- and medium-sized vessels, is increasingly recognized. The varied appearances of vascular involvement reflect the sequela of chronic inflammation and fibrosis and can include aortitis and periaortitis with resultant complications such as aneurysm formation and dissection. A diagnosis of IgG4-related large vessel involvement should be considered when there is known or suspected IgG4-related disease elsewhere. Other organs that are typically affected in IgG4-related disease include the lacrimal and salivary glands, thyroid, pancreas, biliary tree, lungs, kidneys, and meninges. Diagnosis typically requires careful correlation with clinical, imaging, serum, and pathologic findings. Patients may be managed with corticosteroid therapy or the anti-CD20 monoclonal antibody, rituximab, if needed. The varied clinical presentations and imaging features of large vessel involvement are discussed herein. Keywords Vascular, Inflammation, Aorta, IgG4-related Vessel Involvement © RSNA, 2024.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immunoglobulin G4-Related Disease
Limits:
Humans
Language:
En
Journal:
Radiol Cardiothorac Imaging
/
Radiology. Cardiothoracic imaging
Year:
2024
Document type:
Article
Country of publication: