Genetically modified pigs: Emerging animal models for hereditary hearing loss.
Zool Res
; 45(2): 284-291, 2024 Mar 18.
Article
in En
| MEDLINE
| ID: mdl-38485498
ABSTRACT
Hereditary hearing loss (HHL), a genetic disorder that impairs auditory function, significantly affects quality of life and incurs substantial economic losses for society. To investigate the underlying causes of HHL and evaluate therapeutic outcomes, appropriate animal models are necessary. Pigs have been extensively used as valuable large animal models in biomedical research. In this review, we highlight the advantages of pig models in terms of ear anatomy, inner ear morphology, and electrophysiological characteristics, as well as recent advancements in the development of distinct genetically modified porcine models of hearing loss. Additionally, we discuss the prospects, challenges, and recommendations regarding the use pig models in HHL research. Overall, this review provides insights and perspectives for future studies on HHL using porcine models.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Swine Diseases
/
Hearing Loss
/
Hearing Loss, Sensorineural
/
Ear, Inner
Limits:
Animals
Language:
En
Journal:
Zool Res
Year:
2024
Document type:
Article
Affiliation country: