Sequence and structural insights of monoleucine-based sorting motifs contained within the cytoplasmic domains of basolateral proteins.
Front Cell Dev Biol
; 12: 1379224, 2024.
Article
in En
| MEDLINE
| ID: mdl-38495621
ABSTRACT
Delivery to the correct membrane domain in polarized epithelial cells is a critical regulatory mechanism for transmembrane proteins. The trafficking of these proteins is directed by short amino acid sequences known as sorting motifs. In six basolaterally-localized proteins lacking the canonical tyrosine- and dileucine-based basolateral sorting motifs, a monoleucine-based sorting motif has been identified. This review will discuss these proteins with an identified monoleucine-based sorting motif, their conserved structural features, as well as the future directions of study for this non-canonical basolateral sorting motif.
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01-internacional
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MEDLINE
Language:
En
Journal:
Front Cell Dev Biol
Year:
2024
Document type:
Article
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