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Interleukin-12: Structure, Function, and Its Impact in Colorectal Cancer.
Zhu, Ziwei; Peng, Qian; Duan, Xingmei; Li, Jie.
Affiliation
  • Zhu Z; Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, People's Republic of China.
  • Peng Q; Department of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, Peopl
  • Duan X; Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China, Chengdu, People's Republic of. China.
  • Li J; School of Medicine, Southwest Medical University of China, Luzhou, People's Republic of China.
J Interferon Cytokine Res ; 44(4): 158-169, 2024 Apr.
Article in En | MEDLINE | ID: mdl-38498032
ABSTRACT
Interleukin 12 (IL-12) is a heterodimer consisting of 2 subunits, p35 and p40, with unique associations and interacting functions with its family members. IL-12 is one of the most important cytokines regulating the immune system response and is integral to adaptive immunity. IL-12 has shown marked therapeutic potential in a variety of tumor types. This review therefore summarizes the characteristics of IL-12 and its application in tumor treatment, focusing on its antitumor effects in colorectal cancer (CRC) and potential radiosensitization mechanisms. We aim to provide a current reference for IL-12 and other potential CRC treatment strategies.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Interleukin-12 Limits: Humans Language: En Journal: J Interferon Cytokine Res Journal subject: ALERGIA E IMUNOLOGIA Year: 2024 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Interleukin-12 Limits: Humans Language: En Journal: J Interferon Cytokine Res Journal subject: ALERGIA E IMUNOLOGIA Year: 2024 Document type: Article