Association of cardiometabolic and triglyceride-glucose index with left ventricular diastolic function in asymptomatic individuals.
Nutr Metab Cardiovasc Dis
; 34(7): 1590-1600, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38499451
ABSTRACT
BACKGROUND AND AIMS:
Obesity and insulin resistance are associated with left ventricular diastolic dysfunction (LVDD) and increased risk of heart failure. Cardiometabolic index (CMI) and triglyceride glucose (TyG) are new indexes to assess visceral obesity and insulin resistance, respectively. The study aimed to investigate the clinical usefulness of these indexes for identifying LVDD individuals. METHODS ANDRESULTS:
Overall, 1898 asymptomatic individuals were included in this cross-sectional study. Participants underwent anthropometrics, serum biochemical evaluation, and echocardiography. Multiple linear regression analysis revealed that both indexes were independent determinants of diastolic parameters among females; while for males, CMI and TyG were not associated with A velocity. In the multivariate logistic analysis, the proportion of LVDD in the third and fourth quartiles of CMI remained significantly greater than that in the lowest quartile in females (Q3 vs. Q1 odds ratio (OR) = 2.032, 95% confidence interval (CI) 1.181-3.496; Q4 vs. Q1 OR = 2.393, 95% CI 1.347-4.249); while in males, the incidence of LVDD was significantly greater only in the fourth quartile. For TyG, the presence of LVDD in the fourth quartile was significantly greater in both genders. The discriminant values between the CMI (AUC 0.704, 95% CI 0.668-0.739) and TyG (AUC 0.717, 95% CI 0.682-0.752) were similar in females. Both indexes performed better in females than in males to identify LVDD.CONCLUSION:
The CMI and TyG might both serve as effective tools to identify LVDD in routine health check-ups in primary care, mainly in females. With simpler parameters, the CMI could be utilized in medically resource-limited areas.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Triglycerides
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Blood Glucose
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Insulin Resistance
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Biomarkers
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Predictive Value of Tests
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Ventricular Function, Left
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Ventricular Dysfunction, Left
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Diastole
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Asymptomatic Diseases
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Cardiometabolic Risk Factors
Limits:
Adult
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Female
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Humans
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Male
/
Middle aged
Language:
En
Journal:
Nutr Metab Cardiovasc Dis
Journal subject:
ANGIOLOGIA
/
CARDIOLOGIA
/
CIENCIAS DA NUTRICAO
/
METABOLISMO
Year:
2024
Document type:
Article
Affiliation country: