Insights into LINE-1 reverse transcription guide therapy development.
Trends Cancer
; 10(4): 286-288, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38499453
ABSTRACT
Subsets of long interspersed nuclear element 1 (LINE-1) retrotransposons can 'retrotranspose' throughout the human genome at a cost to host cell fitness, as observed in some cancers. Pharmacological inhibition of LINE-1 retrotransposition requires a comprehensive understanding of the LINE-1 ORF2p reverse transcriptase. Two recent publications, by Thawani et al. and Baldwin et al., report structures of LINE-1 ORF2p and address long-standing mechanistic gaps regarding LINE-1 retrotransposition. Both studies will be critical to design new specific inhibitors of the LINE-1 ORF2p reverse transcriptase.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Long Interspersed Nucleotide Elements
/
Reverse Transcription
Limits:
Humans
Language:
En
Journal:
Trends Cancer
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: