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Neopetromin, a Cyclic Tripeptide with a C-N Cross-Link, from the Marine Sponge Neopetrosia sp., That Causes Vacuole Fragmentation in Tobacco BY-2 Cells.
Hitora, Yuki; El-Desoky, Ahmed H; Sadahiro, Yusaku; Sejiyama, Ai; Kinoshita, Amiri; Ise, Yuji; Angkouw, Esther D; Mangindaan, Remy E P; Higaki, Takumi; Tsukamoto, Sachiko.
Affiliation
  • Hitora Y; Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.
  • El-Desoky AH; Pharmaceutical and Drug Industries Research Institute, Pharmacognosy Department, National Research Centre, 33 El-Bohouth Street, Dokki, Giza 12622, Egypt.
  • Sadahiro Y; Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.
  • Sejiyama A; Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.
  • Kinoshita A; Faculty of Science, Kumamoto University, Kurokami, Chuo-ku, Kumamoto 860-8555 Japan.
  • Ise Y; Kuroshio Biological Research Foundation, 560 Nishidomari, Otsuki, Hata, Kochi 788-0333, Japan.
  • Angkouw ED; Faculty of Fisheries and Marine Science, Sam Ratulangi University, Kampus Bahu, Manado 95115, Indonesia.
  • Mangindaan REP; Faculty of Fisheries and Marine Science, Sam Ratulangi University, Kampus Bahu, Manado 95115, Indonesia.
  • Higaki T; Faculty of Science, Kumamoto University, Kurokami, Chuo-ku, Kumamoto 860-8555 Japan.
  • Tsukamoto S; International Research Organization for Advanced Science and Technology, Kumamoto University, Kurokami, Chuo-ku, Kumamoto 860-8555 Japan.
J Nat Prod ; 87(4): 1197-1202, 2024 04 26.
Article in En | MEDLINE | ID: mdl-38503712
ABSTRACT
HPLC-MS analysis revealed the presence of an unreported peptide in the extract of the marine sponge Neopetrosia sp. Its structure was determined as a tripeptide, named neopetromin (1), composed of two tyrosine and one tryptophan residues with a heteroaromatic C-N cross-link between side chains. The absolute configuration of amino acids was determined using Marfey's method after ozonolysis and hydrolysis of 1. Compound 1 promoted vacuole fragmentation in an actin-independent manner in tobacco BY-2 cells.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Porifera / Nicotiana / Vacuoles Limits: Animals Language: En Journal: J Nat Prod Year: 2024 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Porifera / Nicotiana / Vacuoles Limits: Animals Language: En Journal: J Nat Prod Year: 2024 Document type: Article Affiliation country: Country of publication: