Exploiting integrative metabolomics to study host-parasite interactions in Plasmodium infections.
Trends Parasitol
; 40(4): 313-323, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38508901
ABSTRACT
Despite years of research, malaria remains a significant global health burden, with poor diagnostic tests and increasing antimalarial drug resistance challenging diagnosis and treatment. While 'single-omics'-based approaches have been instrumental in gaining insight into the biology and pathogenicity of the Plasmodium parasite and its interaction with the human host, a more comprehensive understanding of malaria pathogenesis can be achieved through 'multi-omics' approaches. Integrative methods, which combine metabolomics, lipidomics, transcriptomics, and genomics datasets, offer a holistic systems biology approach to studying malaria. This review highlights recent advances, future directions, and challenges involved in using integrative metabolomics approaches to interrogate the interactions between Plasmodium and the human host, paving the way towards targeted antimalaria therapeutics and control intervention methods.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plasmodium
/
Malaria
Limits:
Humans
Language:
En
Journal:
Trends Parasitol
Journal subject:
PARASITOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: