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A Screening Approach to the Safe-and-Sustainable-by-Design Development of Advanced Insulation Materials.
Di Battista, Veronica; Ribalta, Carla; Vilsmeier, Klaus; Singh, Dilpreet; Demokritou, Philip; Günther, Eva; Jensen, Keld Alstrup; Dekkers, Susan; Adam, Veronique; Wohlleben, Wendel.
Affiliation
  • Di Battista V; Department of Analytical and Material Science and Department of Experimental Toxicology and Ecology, BASF SE, 67063, Ludwigshafen, Germany.
  • Ribalta C; DTU, Department of Environmental and Resource Engineering, Kgs. Lyngby, Denmark.
  • Vilsmeier K; National Research Centre for the Working Environment, Lerso Parkallé 105, Copenhagen, 2100, Denmark.
  • Singh D; Department of Analytical and Material Science and Department of Experimental Toxicology and Ecology, BASF SE, 67063, Ludwigshafen, Germany.
  • Demokritou P; Center for Nanotechnology and Nanotoxicology, Harvard T.H. Chan School of Public Health, Harvard University, 665 Huntington Ave., Boston, MA, 02115, USA.
  • Günther E; Rutgers University, Piscataway, NJ, 08854, USA.
  • Jensen KA; BASF Construction Additives GmbH, Dr.-Albert-Frank-Str. 32, 83033, Trostberg, Germany.
  • Dekkers S; National Research Centre for the Working Environment, Lerso Parkallé 105, Copenhagen, 2100, Denmark.
  • Adam V; TNO, Unit Health Living & Work, Risk Analysis for Products in Development, Princetonlaan 6, Utrecht, 3584 CB, The Netherlands.
  • Wohlleben W; TEMAS Solutions GmbH, Lätterweg 5, Hausen, 5212, Switzerland.
Small ; : e2311155, 2024 Mar 22.
Article in En | MEDLINE | ID: mdl-38516961
ABSTRACT
Herein, a Safe-and-Sustainable-by-Design (SSbD) screening strategy on four different inorganic aerogel mats and two conventional mineral wools for ranking purposes is demonstrated. Given that they do not consist of particles, the release is first simulated, addressing three occupational exposure scenarios, realistic for their intended use as building insulators. No exposure to consumers nor to the environment is foreseen in the use phase, however, aerosols may be released during mat installation, posing an inhalation risk for workers. All four aerogel mats release more respirable dust than the benchmark materials and 60% thereof deposits in the alveolar region according to modelling tools. The collected aerogel dust allows for subsequent screening of hazard implications via two abiotic assays 1) surface reactivity in human blood serum; 2) biodissolution kinetics in lung simulant fluids. Both aerogels and conventional insulators show similar surface reactivity. Differences in biodissolution are influenced by the specifically designed organic and inorganic structural modifications. Aerogel mats are better-performing insulators (2-fold lower thermal conductivity than the benchmark) However, this work demonstrates how investment decisions can be balanced with safety and sustainability aspects. Concepts of analogy and similarity thus support easily accessible methods to companies for safe and economically viable innovation with advanced materials.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Small Journal subject: ENGENHARIA BIOMEDICA Year: 2024 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Small Journal subject: ENGENHARIA BIOMEDICA Year: 2024 Document type: Article Affiliation country:
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