Comparative proteome analysis revealed potential biomarkers and the underlying immune mechanisms in Vibrio-resistant hybrid grouper, Epinephelus fuscoguttatus â × Epinephelus lanceolatus â.
J Fish Dis
; 47(7): e13940, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38523352
ABSTRACT
Vibrio alginolyticus is the causative agent of vibriosis, a common bacterial infection in grouper aquaculture that is associated with the development of haemorrhagic and non-haemorrhagic ulcerations on the fish. In the present study, comparative proteome analysis was performed on serum samples from Vibrio-resistant and Vibrio-susceptible grouper. Samples were analysed using high-throughput LC-MS/MS and identified 2770 unique peptides that corresponded to 344 proteins. Subsequent analysis identified 21 proteins that were significantly up-regulated in the resistant group compared to the control and the susceptible groups. Those proteins are associated with immunostimulatory effects, signalling and binding cascade, metabolism, and maintaining tissue integrity and physiological condition. Besides, potential protein biomarkers related to the immune system were identified, which could be associated with the disease-resistant phenotype. These data provide insights into the underlying immune mechanism of hybrid groupers upon Vibrio sp. infection.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vibrio Infections
/
Bass
/
Biomarkers
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Proteome
/
Fish Proteins
/
Vibrio alginolyticus
/
Disease Resistance
/
Fish Diseases
Limits:
Animals
Language:
En
Journal:
J Fish Dis
Journal subject:
BIOLOGIA
/
MEDICINA VETERINARIA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: