Isolation of Diverse Simian Arteriviruses Causing Hemorrhagic Disease.
Emerg Infect Dis
; 30(4): 721-731, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38526136
ABSTRACT
Genetically diverse simian arteriviruses (simarteriviruses) naturally infect geographically and phylogenetically diverse monkeys, and cross-species transmission and emergence are of considerable concern. Characterization of most simarteriviruses beyond sequence analysis has not been possible because the viruses fail to propagate in the laboratory. We attempted to isolate 4 simarteriviruses, Kibale red colobus virus 1, Pebjah virus, simian hemorrhagic fever virus, and Southwest baboon virus 1, by inoculating an immortalized grivet cell line (known to replicate simian hemorrhagic fever virus), primary macaque cells, macrophages derived from macaque induced pluripotent stem cells, and mice engrafted with macaque CD34+-enriched hematopoietic stem cells. The combined effort resulted in successful virus isolation; however, no single approach was successful for all 4 simarteriviruses. We describe several approaches that might be used to isolate additional simarteriviruses for phenotypic characterization. Our results will expedite laboratory studies of simarteriviruses to elucidate virus-host interactions, assess zoonotic risk, and develop medical countermeasures.
Key words
Arteriviridae; KRCV-1; Kibale red colobus virus; NHP; PBJV; Pebjah virus; SHFV; SWBV; Simarterivirinae; United States; arterivirid; arterivirus; engraft; iPSC; induced pluripotent stem cell; nonhuman primate; simarterivirin; simarterivirus; simian hemorrhagic fever virus; southwest baboon virus; viruses; zoonoses
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arterivirus
Limits:
Animals
Language:
En
Journal:
Emerg Infect Dis
Journal subject:
DOENCAS TRANSMISSIVEIS
Year:
2024
Document type:
Article
Country of publication: