Role of dendritic cells in spinal cord injury.
CNS Neurosci Ther
; 30(3): e14593, 2024 03.
Article
in En
| MEDLINE
| ID: mdl-38528832
ABSTRACT
BACKGROUND:
Inflammation can worsen spinal cord injury (SCI), with dendritic cells (DCs) playing a crucial role in the inflammatory response. They mediate T lymphocyte differentiation, activate microglia, and release cytokines like NT-3. Moreover, DCs can promote neural stem cell survival and guide them toward neuron differentiation, positively impacting SCI outcomes.OBJECTIVE:
This review aims to summarize the role of DCs in SCI-related inflammation and identify potential therapeutic targets for treating SCI.METHODS:
Literature in PubMed and Web of Science was reviewed using critical terms related to DCs and SCI.RESULTS:
The study indicates that DCs can activate microglia and astrocytes, promote T-cell differentiation, increase neurotrophin release at the injury site, and subsequently reduce secondary brain injury and enhance functional recovery in the spinal cord.CONCLUSIONS:
This review highlights the repair mechanisms of DCs and their potential therapeutic potential for SCI.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spinal Cord Injuries
/
Neural Stem Cells
Limits:
Humans
Language:
En
Journal:
CNS Neurosci Ther
Journal subject:
NEUROLOGIA
/
TERAPEUTICA
Year:
2024
Document type:
Article
Affiliation country: