Differential diagnosis of gastric low- and high grade dysplasia using C6orf15 protein.
Ann Diagn Pathol
; 71: 152298, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38547762
ABSTRACT
OBJECTIVE:
To investigate the expression of C6orf15 protein in gastric endoscopic biopsy specimens and its usage as an ancillary diagnostic biomarker in determining the grade of gastric dysplasia.METHODS:
We selected 102 patients with gastric endoscopic biopsy specimens from Jinling Hospital. These were divided into four groups 22 cases of gastric mucosal benign lesions, 28 with low-grade dysplasia (LGD, intestinal-type 21 casesï¼foveolar-type 7cases), 28 with high-grade dysplasia (HGD, intestinal-type 20 casesï¼foveolar-type 8 cases), and 24 cases of gastric adenocarcinoma. We examined the expressions of C6orf15, P53, and Ki67 in 102 gastric endoscopic biopsy specimens, including 47 cases with accompanying endoscopic submucosal dissection (ESD) specimens, using immunohistochemistry.RESULTS:
In gastric HGD and gastric adenocarcinoma, the c6orf15 protein exhibits diffuse and strong cytoplasmic expression in tumor cells. Conversely, in gastric LGD and benign gastric mucosal lesions, the c6orf15 protein shows negative or faint yellow cytoplasmic staining. The expression rate of C6orf15 in high-grade gastric dysplasia (HGD, 93 %) and gastric adenocarcinoma (100 %) was significantly higher than in the gastric mucosal benign lesion group (0 %) and the low-grade dysplasia (LGD, 7 %) group (P < 0.001).CONCLUSION:
The detection of C6orf15 protein expression could serve as a valuable adjunctive diagnostic tool for distinguishing between gastric HGD, LGD, and benign lesions. The combined assessment of C6orf15, P53, and Ki67 expressions may be beneficial in determining the grade of gastric dysplasia and evaluating the risk of progression in gastric mucosal lesions in clinical practice.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stomach Neoplasms
/
Adenocarcinoma
/
Biomarkers, Tumor
/
Gastric Mucosa
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Ann Diagn Pathol
Journal subject:
PATOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: