Effects of Heavy Metal Co-Exposure on the formation of DNA Adducts from Aristolochic Acid I: Implications for Balkan Endemic Nephropathy Development.
Chem Res Toxicol
; 37(4): 545-548, 2024 Apr 15.
Article
in En
| MEDLINE
| ID: mdl-38551460
ABSTRACT
Accumulated evidence has shown that Balkan endemic nephropathy (BEN) is a multifactorial environmental disease, with exposure to aristolochic acids (AA), and the associated DNA adduct formation, as a key causative factor of BEN development. Here, we show that coexposure to arsenic, cadmium, and iron increases the DNA adduct formation of AA in cultured kidney cells, while exhibiting both an exposure concentration and duration dependence. In contrast, coexposure to calcium and copper showed a decreasing DNA adduct formation. Because DNA damage is responsible for both the nephrotoxicity and carcinogenicity of AA, these results shed greater light on the endemic nature of BEN.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Balkan Nephropathy
/
Metals, Heavy
/
Aristolochic Acids
Limits:
Humans
Language:
En
Journal:
Chem Res Toxicol
Journal subject:
TOXICOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: