Mechanisms and consequences of excess exercise ventilation in fibrosing interstitial lung disease.
Respir Physiol Neurobiol
; 325: 104255, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38555042
ABSTRACT
The causes and consequences of excess exercise ventilation (EEV) in patients with fibrosing interstitial lung disease (f-ILD) were explored. Twenty-eight adults with f-ILD and 13 controls performed an incremental cardiopulmonary exercise test. EEV was defined as ventilation-carbon dioxide output (â©E-â©CO2) slope ≥36â¯L/L. Patients showed lower pulmonary function and exercise capacity compared to controls. Lower DLCO was related to higher â©E-â©CO2 slope in patients (P<0.05). 13/28 patients (46.4%) showed EEV, reporting higher dyspnea scores (P=0.033). Patients with EEV showed a higher dead space (VD)/tidal volume (VT) ratio while O2 saturation dropped to a greater extent during exercise compared to those without EEV. Higher breathing frequency and VT/inspiratory capacity ratio were observed during exercise in the former group (P<0.05). An exaggerated ventilatory response to exercise in patients with f-ILD is associated with a blunted decrease in the wasted ventilation in the physiological dead space and greater hypoxemia, prompting higher inspiratory constraints and breathlessness.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Exercise
/
Lung Diseases, Interstitial
/
Exercise Test
Limits:
Aged
/
Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Respir Physiol Neurobiol
Year:
2024
Document type:
Article