Differences and similarities between innate immune evasion strategies of human coronaviruses.
Curr Opin Microbiol
; 79: 102466, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38555743
ABSTRACT
So far, seven coronaviruses have emerged in humans. Four recurring endemic coronaviruses cause mild respiratory symptoms. Infections with epidemic Middle East respiratory syndrome-related coronavirus or severe acute respiratory syndrome coronavirus (SARS-CoV)-1 are associated with high mortality rates. SARS-CoV-2 is the causative agent of the coronavirus disease 2019 pandemic. To establish an infection, coronaviruses evade restriction by human innate immune defenses, such as the interferon system, autophagy and the inflammasome. Here, we review similar and distinct innate immune manipulation strategies employed by the seven human coronaviruses. We further discuss the impact on pathogenesis, zoonotic emergence and adaptation. Understanding the nature of the interplay between endemic/epidemic/pandemic coronaviruses and host defenses may help to better assess the pandemic potential of emerging coronaviruses.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Coronavirus Infections
/
Immune Evasion
/
Immunity, Innate
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Opin Microbiol
Journal subject:
MICROBIOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: