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Prestalk-like positioning of de-differentiated cells in the social amoeba Dictyostelium discoideum.
Shirokawa, Yuka; Shimada, Masakazu; Shimada, Nao; Sawai, Satoshi.
Affiliation
  • Shirokawa Y; Graduate School of Arts and Sciences, University of Tokyo, Tokyo, 153-8902, Japan. shirokawa.yuka@gmail.com.
  • Shimada M; Graduate School of Arts and Sciences, University of Tokyo, Tokyo, 153-8902, Japan.
  • Shimada N; Graduate School of Arts and Sciences, University of Tokyo, Tokyo, 153-8902, Japan.
  • Sawai S; Graduate School of Arts and Sciences, University of Tokyo, Tokyo, 153-8902, Japan.
Sci Rep ; 14(1): 7677, 2024 04 01.
Article in En | MEDLINE | ID: mdl-38561423
ABSTRACT
The social amoeba Dictyostelium discoideum switches between solitary growth and social fruitification depending on nutrient availability. Under starvation, cells aggregate and form fruiting bodies consisting of spores and altruistic stalk cells. Once cells socially committed, they complete fruitification, even if a new source of nutrients becomes available. This social commitment is puzzling because it hinders individual cells from resuming solitary growth quickly. One idea posits that traits that facilitate premature de-commitment are hindered from being selected. We studied outcomes of the premature de-commitment through forced refeeding. Our results show that when refed cells interacted with non-refed cells, some of them became solitary, whereas a fraction was redirected to the altruistic stalk, regardless of their original fate. The refed cells exhibited reduced cohesiveness and were sorted out during morphogenesis. Our findings provide an insight into a division of labor of the social amoeba, in which less cohesive individuals become altruists.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dictyostelium / Amoeba Limits: Humans Language: En Journal: Sci Rep / Sci. rep. (Nat. Publ. Group) / Scientific reports (Nature Publishing Group) Year: 2024 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dictyostelium / Amoeba Limits: Humans Language: En Journal: Sci Rep / Sci. rep. (Nat. Publ. Group) / Scientific reports (Nature Publishing Group) Year: 2024 Document type: Article Affiliation country: Country of publication: