Association between obesity and cancer risk in adults with HIV in Korea.
AIDS
; 38(9): 1386-1394, 2024 07 15.
Article
in En
| MEDLINE
| ID: mdl-38597513
ABSTRACT
INTRODUCTION:
This study aimed to investigate the association between obesity and cancer risk as well as site-specific cancer risks in adults with HIV using a nationwide health screening database in Korea.METHODS:
Of the 16,671 adults with a new diagnosis of HIV from 2004 to 2020, 456 incident cancer cases and 1814 individually matched controls by sex, year of birth, year of HIV diagnosis, and follow-up duration (1ââ4 ratio) were included in this nested case-control study. The association between obesity (BMI ≥25âkg/m 2 ) and cancer risks was estimated and presented as odds ratios (ORs) and 95% confidence intervals (95% CIs).RESULTS:
Of the 456 cancer incident cases, there were 146 AIDS-defining cancer cases and 310 non-AIDS-defining cancer cases. Compared with nonobese adults with HIV, obese adults with HIV were at higher risk of non-AIDS-defining cancer (ORâ=â1.478, 95% CIâ=â1.118-1.955). Otherwise, the overall risk of AIDS-defining cancer (ORâ=â0.816, 95% CIâ=â0.520-1.279) and each type of AIDS-defining cancer (Kaposi sarcoma and non-Hodgkin's lymphoma) were not high in obese adults with HIV. Of the specific types of non-AIDS-defining cancers, obesity was associated with an increased risk of colorectal cancer (ORâ=â3.090, 95% CIâ=â1.110-8.604) and liver, bile duct, and pancreatic cancers (ORâ=â2.532, 95% CIâ=â1.141-5.617).CONCLUSION:
Obesity, which is one of the important health concerns in HIV management, was associated with an increased risk of non-AIDS-defining cancer but not AIDS-defining cancer.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
HIV Infections
/
Neoplasms
/
Obesity
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
AIDS
/
AIDS (Lond.)
/
AIDS (London, England)
Journal subject:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Year:
2024
Document type:
Article
Country of publication: