End-tidal carbon monoxide concentrations measured within 48 hours of birth predict hemolytic hyperbilirubinemia.
J Perinatol
; 44(6): 897-901, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38627593
ABSTRACT
OBJECTIVES:
To determine, among neonates at-risk for hyperbilirubinemia, whether measuring end-tidal carbon monoxide concentration (ETCOc) twice before 48 hours could identify those who would develop hyperbilirubinemia and differentiate hemolytic vs. non-hemolytic causes.METHODS:
Prospective study on neonates meeting criteria "at-risk for hyperbilirubinemia." Routine bilirubin measurements and 10-day follow-up were used to categorize neonates as; (1) normal (no hyperbilirubinemia, all bilirubins <95th percentile of Bhutani nomogram), (2) having hemolytic hyperbilirubinemia (bilirubin ≥95th percentile, DAT+, elevated retic, or G6PD+), or (3) having non-hemolytic hyperbilirubinemia.RESULTS:
386 neonates were enrolled. 321 (83%) did not develop hyperbilirubinemia and 65 (17%) did, of which 29 were judged hemolytic and 36 non-hemolytic. High ETCOc differentiated the hemolytic group (p < 0.001). First-day ETCOc correlated with bilirubin and with reticulocyte count (r = 0.896 and 0.878) and sensitivity and specificity for predicting hyperbilirubinemia were excellent (83% and 95%).CONCLUSIONS:
ETCO measurement in the first 48 hours after birth predicts hemolytic hyperbilirubinemia.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bilirubin
/
Carbon Monoxide
/
Hyperbilirubinemia, Neonatal
Limits:
Female
/
Humans
/
Male
/
Newborn
Language:
En
Journal:
J Perinatol
Journal subject:
PERINATOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: