Modulation of Cellular Stemness for Enhanced Fat Grafting.
Plast Reconstr Surg Glob Open
; 12(4): e5770, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38660335
ABSTRACT
Low volumetric retention limits the utility of fat grafting. Although inclusion of stem cells and platelet-rich plasma have been proposed to enhance graft retention, accumulating evidence has failed to show a clear benefit. Here, we propose a strategy to pharmacologically enhance stemness of stem and progenitor cell populations in fat grafts to promote increased volume retention and tissue health. We also propose how to integrate stemness-promoting and differentiation-promoting therapies such as platelet-rich plasma, and viability promoting therapies within the common fat grafting workflow to achieve optimal fat grafting results.
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1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Plast Reconstr Surg Glob Open
Year:
2024
Document type:
Article
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