Neuroinflammation induced by amyloid-forming pancreatic amylin: Rationale for a mechanistic hypothesis.
Biophys Chem
; 310: 107252, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38663120
ABSTRACT
Amylin is a systemic neuroendocrine hormone co-expressed and co-secreted with insulin by pancreatic ß-cells. In persons with thype-2 diabetes, amylin forms pancreatic amyloid triggering inflammasome and interleukin-1ß signaling and inducing ß-cell apoptosis. Here, we summarize recent progress in understanding the potential link between amyloid-forming pancreatic amylin and Alzheimer's disease (AD). Clinical data describing amylin pathology in AD alongside mechanistic studies in animals are reviewed. Data from multiple research teams indicate higher amylin concentrations are associated with increased frequency of cognitive impairment and amylin co-aggregates with ß-amyloid in AD-type dementia. Evidence from rodent models further suggests cerebrovascular amylin accumulation as a causative factor underlying neurological deficits. Analysis of relevant literature suggests that modulating the amylin-interleukin-1ß pathway may provide an approach for counteracting neuroinflammation in AD.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Islet Amyloid Polypeptide
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Alzheimer Disease
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Neuroinflammatory Diseases
Limits:
Animals
/
Humans
Language:
En
Journal:
Biophys Chem
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: