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Molecular characterization of plasma virome of hepatocellular carcinoma (HCC) patients.
Ullah Khan, Niamat; Sadiq, Asma; Khan, Jadoon; Basharat, Nosheen; Hassan, Zulfiqar Ul; Ali, Ijaz; Shah, Tawaf Ali; Bourhia, Mohammed; Bin Jardan, Yousef A; Wondmie, Gezahign Fentahun.
Affiliation
  • Ullah Khan N; Molecular Virology Laboratory, Department of Biosciences, COMSATS University, Islamabad, Pakistan.
  • Sadiq A; Department of Microbiology, University of Jhang, Punjab, Pakistan.
  • Khan J; Molecular Virology Laboratory, Department of Biosciences, COMSATS University, Islamabad, Pakistan. jadoonkhan@bs.qau.edu.pk.
  • Basharat N; Department of Allied Health Sciences, Iqra University, Chak Shahzad Campus, Islamabad, Pakistan. jadoonkhan@bs.qau.edu.pk.
  • Hassan ZU; Department of Microbiology, University of Jhang, Punjab, Pakistan.
  • Ali I; Department of Allied Health Sciences, Iqra University, Chak Shahzad Campus, Islamabad, Pakistan.
  • Shah TA; Molecular Virology Laboratory, Department of Biosciences, COMSATS University, Islamabad, Pakistan.
  • Bourhia M; Center for Applied Mathematics and Bioinformatics (CAMB), Gulf University for Science and Technology, West Mishref, Kuwait.
  • Bin Jardan YA; College of Agriculture Engineering and Food Science, Shandong University of Technology, Zibo, 255000, China.
  • Wondmie GF; Laboratory of Biotechnology and Natural Resources Valorization, Faculty of Sciences, Ibn Zohr University, Agadir, 80060, Morocco. m.bourhia@uiz.ac.ma.
AMB Express ; 14(1): 46, 2024 Apr 25.
Article in En | MEDLINE | ID: mdl-38664337
ABSTRACT
Hepatocellular carcinoma (HCC) stands as the most common cancer type, arising from various causes, and responsible for a substantial number of cancer-related fatalities. Recent advancements in viral metagenomics have empowered scientists to delve into the intricate diversity of the virosphere, viral evolution, interactions between viruses and their hosts, and the identification of viral causes behind disease outbreaks, the development of specific symptoms, and their potential role in altering the host's physiology. The present study had the objective of "Molecular Characterization of HBV, HCV, anelloviruses, CMV, SENV-D, SENV-H, HEV, and HPV viruses among individuals suffering from HCC." A total of 381 HCC patients contributed 10 cc of blood each for this study. The research encompassed the assessment of tumor markers, followed by molecular characterization of HBV, HCV, Anelloviruses (TTV, TTMV, and TTMDV), SENV-H and SENV-D viruses, HEV, CMV, and HPV, as well as histopathological examinations. The outcomes of this study revealed that majority of the HCC patients 72.4% (276/381) were male as compared to females. HCV infection, at 76.4% (291 out of 381), exhibited a significant association (p < 0.05) with HCC. Most patients displayed singular lesions in the liver, with Child Pugh Score Type B being the predominant finding in 45.2% of cases. Plasma virome analysis indicated the prevalence of TTMDV (75%), followed by TTMV (70%) and TTV (42.1%) among anelloviruses in HCC patients. Similarly, SENV-H (52%) was followed by SENV-D (20%), with co-infections at 15%. The presence of CMV and HEV among the HCC patients was recorded 5% each however 3.5% of the patients showed the presence of HPV. In conclusion, this study underscores that HCC patients serve as reservoirs for various pathogenic and non-pathogenic viruses, potentially contributing to the development, progression, and severity of the disease.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: AMB Express Year: 2024 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: AMB Express Year: 2024 Document type: Article Affiliation country: Country of publication: