Targeting Wnt/ß-catenin signaling and its interplay with TGF-ß and Notch signaling pathways for the treatment of chronic wounds.
Cell Commun Signal
; 22(1): 244, 2024 Apr 26.
Article
in En
| MEDLINE
| ID: mdl-38671406
ABSTRACT
Wound healing is a tightly regulated process that ensures tissue repair and normal function following injury. It is modulated by activation of pathways such as the transforming growth factor-beta (TGF-ß), Notch, and Wnt/ß-catenin signaling pathways. Dysregulation of this process causes poor wound healing, which leads to tissue fibrosis and ulcerative wounds. The Wnt/ß-catenin pathway is involved in all phases of wound healing, primarily in the proliferative phase for formation of granulation tissue. This review focuses on the role of the Wnt/ß-catenin signaling pathway in wound healing, and its transcriptional regulation of target genes. The crosstalk between Wnt/ß-catenin, Notch, and the TGF-ß signaling pathways, as well as the deregulation of Wnt/ß-catenin signaling in chronic wounds are also considered, with a special focus on diabetic ulcers. Lastly, we discuss current and prospective therapies for chronic wounds, with a primary focus on strategies that target the Wnt/ß-catenin signaling pathway such as photobiomodulation for healing diabetic ulcers.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Wound Healing
/
Transforming Growth Factor beta
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Receptors, Notch
/
Wnt Signaling Pathway
Limits:
Animals
/
Humans
Language:
En
Journal:
Cell Commun Signal
Year:
2024
Document type:
Article
Affiliation country: