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Melanocyte-Keratinocyte Transplantation in Post-Burn Leukoderma Scars: Preliminary Experience Using a Modified Technique.
Louri, N A; Dey, N; De Sousa, R F; AlHasan, R N; Abdelhamid, M M.
Affiliation
  • Louri NA; Plastic Surgery and Burn Unit, Bahrain Defence Force Royal Medical Services, Military Hospital, Bahrain.
  • Dey N; Plastic Surgery and Burn Unit, Bahrain Defence Force Royal Medical Services, Military Hospital, Bahrain.
  • De Sousa RF; Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, India.
  • AlHasan RN; Plastic Surgery and Burn Unit, Bahrain Defence Force Royal Medical Services, Military Hospital, Bahrain.
  • Abdelhamid MM; Plastic Surgery and Burn Unit, Bahrain Defence Force Royal Medical Services, Military Hospital, Bahrain.
Ann Burns Fire Disasters ; 35(4): 306-314, 2022 Dec.
Article in En | MEDLINE | ID: mdl-38680627
ABSTRACT
Post-burn leukoderma, commonly affecting the African and Asian communities, results from deep dermal burns. The associated stigma exacerbates the condition and significantly affects the rehabilitation and reintegration of post-burn survivors into society. Melanocyte-keratinocyte transplantation (MKTP) is a promising single-stage treatment for repigmentation in vitiligo. However, its use in post-burn leukoderma is undetermined. This study aims to evaluate the MKTP treatment in post-burn leukoderma patches. Six patients (five males and one female, mean age = 29±5.51 years) with ten patches of post-burn leukoderma underwent single-stage MKTP without adjuvant pigmentation therapy. The postoperative follow-up period ranged from twelve to twenty-four months for all the patients. The average size of leukoderma treated was 16.25±9 cm2. Repigmentation was observed in 92.16±11.05% of the total treated area by the end of one year after MKTP application. All six patients were satisfied with the treatment outcome. MKTP without adjuvant therapy is an effective surgical treatment to treat post-burn leukoderma patches. Future studies should cover a larger sample over a longer follow-up period.
Le vitiligo cicatriciel après brûlure est fréquent dans les populations africaines et asiatiques, affectant significativement la réintégration sociale des patients. La TMK est une technique en 1 temps de repigmentation du vitiligo, prometteuse, qui n'a pas été évaluée dans ce contexte. Nous l'avons utilisée, sans traitement adjuvant, chez 6 patients (5 hommes et 1 femme de 29 +/- 5,51 ans) sur 10 zones dépigmentées (surface de 16,25 +/- 9 cm2), avec un recul de 12 à 32 mois. À un an, une repigmentation a été observée sur 92,16 +/- 11,05% de la surface traitée et tous les patients étaient satisfaits du résultat. La TMK isolée semble donc être efficace pour traiter le vitiligo cicatriciel après brûlures, des études sur des zones plus étendues et avec un suivi à plus long terme restant nécessaires.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Ann Burns Fire Disasters Year: 2022 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Ann Burns Fire Disasters Year: 2022 Document type: Article Affiliation country: