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Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol.
Zheng, Zhi-Hua; Wang, Jiao-Jiao; Lin, Jiu-Guo; Ye, Wei-le; Zou, Jia-Mi; Liang, Li-Yin; Yang, Ping-Lian; Qiu, Wan-Lu; Li, Yuan-Yuan; Yang, Si-Jia; Zhao, Man; Zhou, Qing; Li, Cheng-Zhi; Li, Min; Li, Zhuo-Ming; Zhang, Dong-Mei; Liu, Pei-Qing; Liu, Zhi-Ping.
Affiliation
  • Zheng ZH; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, 510632, China.
  • Wang JJ; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, China.
  • Lin JG; Laboratory of Pharmacology & Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
  • Ye WL; National and Local United Engineering Lab of Druggability and New Drugs Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
  • Zou JM; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, 510632, China.
  • Liang LY; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, China.
  • Yang PL; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, 510632, China.
  • Qiu WL; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, China.
  • Li YY; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, 510632, China.
  • Yang SJ; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, China.
  • Zhao M; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, 510632, China.
  • Zhou Q; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, China.
  • Li CZ; Laboratory of Pharmacology & Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
  • Li M; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, 510632, China.
  • Li ZM; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, China.
  • Zhang DM; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, 510632, China.
  • Liu PQ; Department of Ophthalmology, the First Affiliated Hospital, Jinan University, Guangzhou, 510006, China.
  • Liu ZP; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, 510632, China.
Acta Pharmacol Sin ; 45(9): 1879-1897, 2024 Sep.
Article in En | MEDLINE | ID: mdl-38689095
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cellular Senescence / Cilostazol / Inflammation / Membrane Proteins / Mice, Inbred C57BL / Mitochondria Limits: Animals / Humans / Male Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2024 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cellular Senescence / Cilostazol / Inflammation / Membrane Proteins / Mice, Inbred C57BL / Mitochondria Limits: Animals / Humans / Male Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2024 Document type: Article Affiliation country: Country of publication: