Sex differences in the extent of acute axonal pathologies after experimental concussion.
Acta Neuropathol
; 147(1): 79, 2024 05 05.
Article
in En
| MEDLINE
| ID: mdl-38705966
ABSTRACT
Although human females appear be at a higher risk of concussion and suffer worse outcomes than males, underlying mechanisms remain unclear. With increasing recognition that damage to white matter axons is a key pathologic substrate of concussion, we used a clinically relevant swine model of concussion to explore potential sex differences in the extent of axonal pathologies. At 24 h post-injury, female swine displayed a greater number of swollen axonal profiles and more widespread loss of axonal sodium channels than males. Axon degeneration for both sexes appeared to be related to individual axon architecture, reflected by a selective loss of small caliber axons after concussion. However, female brains had a higher percentage of small caliber axons, leading to more extensive axon loss after injury compared to males. Accordingly, sexual dimorphism in axonal size is associated with more extensive axonal pathology in females after concussion, which may contribute to worse outcomes.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Axons
/
Brain Concussion
/
Sex Characteristics
/
Disease Models, Animal
Limits:
Animals
Language:
En
Journal:
Acta Neuropathol
Year:
2024
Document type:
Article
Affiliation country: