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Activation of feedforward wiring in adult hippocampal neurons by the basic-helix-loop-helix transcription factor Ascl4.
Luo, Wenshu; Egger, Matteo; Cruz-Ochoa, Natalia; Tse, Alice; Maloveczky, Gyula; Tamás, Bálint; Lukacsovich, David; Seng, Charlotte; Amrein, Irmgard; Lukacsovich, Tamás; Wolfer, David; Földy, Csaba.
Affiliation
  • Luo W; Laboratory of Neural Connectivity, Brain Research Institute, Faculties of Medicine and Science, University of Zürich, Zürich 8057, Switzerland.
  • Egger M; Laboratory of Neural Connectivity, Brain Research Institute, Faculties of Medicine and Science, University of Zürich, Zürich 8057, Switzerland.
  • Cruz-Ochoa N; Adaptive Brain Circuits in Development and Learning (AdaBD), University Research Priority Program (URPP), University of Zürich, Zürich 8057, Switzerland.
  • Tse A; Laboratory of Neural Connectivity, Brain Research Institute, Faculties of Medicine and Science, University of Zürich, Zürich 8057, Switzerland.
  • Maloveczky G; Adaptive Brain Circuits in Development and Learning (AdaBD), University Research Priority Program (URPP), University of Zürich, Zürich 8057, Switzerland.
  • Tamás B; Laboratory of Neural Connectivity, Brain Research Institute, Faculties of Medicine and Science, University of Zürich, Zürich 8057, Switzerland.
  • Lukacsovich D; Laboratory of Neural Connectivity, Brain Research Institute, Faculties of Medicine and Science, University of Zürich, Zürich 8057, Switzerland.
  • Seng C; Laboratory of Neural Connectivity, Brain Research Institute, Faculties of Medicine and Science, University of Zürich, Zürich 8057, Switzerland.
  • Amrein I; Laboratory of Neural Connectivity, Brain Research Institute, Faculties of Medicine and Science, University of Zürich, Zürich 8057, Switzerland.
  • Lukacsovich T; Laboratory of Neural Connectivity, Brain Research Institute, Faculties of Medicine and Science, University of Zürich, Zürich 8057, Switzerland.
  • Wolfer D; Institute of Anatomy, Faculty of Medicine, University of Zürich, Zürich 8057, Switzerland.
  • Földy C; Laboratory of Neural Connectivity, Brain Research Institute, Faculties of Medicine and Science, University of Zürich, Zürich 8057, Switzerland.
PNAS Nexus ; 3(5): pgae174, 2024 May.
Article in En | MEDLINE | ID: mdl-38711810
ABSTRACT
Although evidence indicates that the adult brain retains a considerable capacity for circuit formation, adult wiring has not been broadly considered and remains poorly understood. In this study, we investigate wiring activation in adult neurons. We show that the basic-helix-loop-helix transcription factor Ascl4 can induce wiring in different types of hippocampal neurons of adult mice. The new axons are mainly feedforward and reconfigure synaptic weights in the circuit. Mice with the Ascl4-induced circuits do not display signs of pathology and solve spatial problems equally well as controls. Our results demonstrate reprogrammed connectivity by a single transcriptional factor and provide insights into the regulation of brain wiring in adults.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: PNAS Nexus Year: 2024 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: PNAS Nexus Year: 2024 Document type: Article Affiliation country: Country of publication: