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Marcytoglobosins A and B, Cytochalasans From a Marine Sponge Associated Chaetomium globosum 162105 Fungus.
Miao, Xian-Xian; Hong, Li-Li; Liu, Hong-Yan; Shang, Ru-Yi; Jiao, Wei-Hua; Xu, Shi-Hai; Lin, Hou-Wen.
Affiliation
  • Miao XX; Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou, 510632, China.
  • Hong LL; Research Center for Marine Drugs, State Key Laboratory of Microbial Metabolism, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
  • Liu HY; Research Center for Marine Drugs, State Key Laboratory of Microbial Metabolism, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
  • Shang RY; Research Center for Marine Drugs, State Key Laboratory of Microbial Metabolism, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
  • Jiao WH; Research Center for Marine Drugs, State Key Laboratory of Microbial Metabolism, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
  • Xu SH; Research Center for Marine Drugs, State Key Laboratory of Microbial Metabolism, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
  • Lin HW; Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou, 510632, China.
Chem Biodivers ; 21(7): e202400832, 2024 Jul.
Article in En | MEDLINE | ID: mdl-38712949
ABSTRACT
Two new cytochalasans, marcytoglobosins A (1) and B (2) were isolated from the marine sponge associated fungus Chaetomium globosum 162105, along with six known compounds (3-8). The complete structures of two new compounds were determined based on 1D/2D NMR and HR-MS spectroscopic analyses coupled with ECD calculations. All eight isolates were evaluated for their antibacterial activity. Among them, compounds 3-8 displayed antibacterial effects against Staphylococcus epidermidis, Bacillus thuringiensis, Pseudomonas syringae pv. Actinidiae, Vibrio alginolyticus, and Edwardsiella piscicida with minimum inhibitory concentration (MIC) values ranging from 10 to 25 µg/mL.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Porifera / Microbial Sensitivity Tests / Chaetomium / Anti-Bacterial Agents Limits: Animals Language: En Journal: Chem Biodivers Journal subject: BIOQUIMICA / QUIMICA Year: 2024 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Porifera / Microbial Sensitivity Tests / Chaetomium / Anti-Bacterial Agents Limits: Animals Language: En Journal: Chem Biodivers Journal subject: BIOQUIMICA / QUIMICA Year: 2024 Document type: Article Affiliation country: